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  Prof Alexander Nyarko (NMIMR, University of Ghana)                                  
 
Professor Nyarko is the Director of the Noguchi Memorial Institute for Medical Research at the University of Ghana. He holds a B.Sc. (Honours) and MSc degrees in Biochemistry from the same university, and a PhD in Pharmacology and Toxicology from the Philadelphia College of Pharmacy and Science (currently the University of the Sciences in Philadelphia), Pennsylvania, USA. His research for the past two decades has focused largely on chronic diseases with special interest in studies into efficacy and safety of traditional treatments for diseases such as diabetes mellitus, hypertension and cancers among others, as well as chemical/drug-induced toxic injury and environmental toxicology. Professor Nyarko has previously served as a visiting Professor to the Osaka City University in Japan, advisor to WHO/Afro Expert Committee on Traditional Medicine and a Fulbright Research Scholar at the University of North Carolina, Chapel Hill USA.

Selected publications

Nakagawa-Goto K, Nakamura S, Bastow KF, Nyarko A, Peng CY, Lee FY, Lee FC, Lee KH.
(2007) Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents. Bioorg Med Chem Lett. 17 2894-8.

Lin L, Shi Q, Nyarko AK, Bastow KF, Wu CC, Su CY, Shih CC, Lee KH (2006) Antitumor agents. 250.
Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents. J Med Chem. 49(13):3963-72.

Nyarko, A.K., Okine, L.K.N., Wedzi, R.K., Addo, P.A., Ofosuhene, M. (2005) Sub-chronic toxicity
studies of the anti-diabetic herbal preparation add-199 in the rat: absence of organ Toxicity and modulation of cytochrome P450 J Ethnopharmacol. 97(1):319-325

Ding P, Chen D, Bastow KF, Nyarko AK, Wang X, Lee K-H (2004) Cytotoxic Isoprenylated
Flavonoids from the Roots of Sophora flavescens. Helvetica Chimica Acta 87 2574-2580

Nyarko, A.K., Asare-Anane, H., Ofosuhene, M. Addy, M.E., Teye, K., Addo, P.G. (2003) Aqueous
extract of Ocimum canum decreases levels of fasting blood glucose and free radicals and increases anti-atherogenic lipid levels in mice. Vascular Pharmacology 39(6) 273-279.

Norikula T., Kennedy, D.O., Nyarko, A.K., Kojima, K., Matsui-Yuasa, I. (2002) Protective effect of
Aloe extract against the cytotoxicity of 1,4-Naphthoquinone in isolated rat hepatocytes involves modulation of cellular thiol levels. Pharmacology and Toxicology 90, 278-284.

Nyarko, A.K., Ankrah, N-A, Ofosuhene, M., Sittie, A.A. (1999) Acute and Subchronic Evaluation of
Indigofera arrecta: Absence of both toxicity and modulation of selected cytochrome P450 isozymes in ddY mice. Phytotherapy Research 13 686-688.
 
   

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